补充 近交系小鼠基因模型
这个我怕有人喷我,附文献原文吧…
TheAvymutation initially arose spontaneously in C3H/HeJ mice in 1962 . Animals carrying this mutation were backcrossed with C57BL/6J mice, followed by more than 220 generations of sibling mating. This has resulted in generation ofAvymice with a genetically invariant background that is 93% C57BL/6J .
这个我怕有人喷我,附文献原文吧…
TheAvymutation initially arose spontaneously in C3H/HeJ mice in 1962 . Animals carrying this mutation were backcrossed with C57BL/6J mice, followed by more than 220 generations of sibling mating. This has resulted in generation ofAvymice with a genetically invariant background that is 93% C57BL/6J .